Human insulin allergy: four case reports

Eur Ann Allergy Clin Immunol. 2010 Dec;42(6):221-3.


Insulin allergy was not uncommon in the past, but has lowered with the introduction of human recombinant insulin. Human recombinant insulin allergy is a rare condition, now reported in less than 1% of treated patients. However, it is a serious condition that requires an immediate allergological work-up. In this study, we describe 4 cases of IgE-mediated reaction to human recombinant insulin, emphasizing some practical aspects in diagnosis and treatment.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Drug Hypersensitivity / diagnosis*
  • Drug Hypersensitivity / therapy
  • Female
  • Humans
  • Immunoglobulin E / immunology
  • Insulin / adverse effects*
  • Male
  • Middle Aged
  • Recombinant Proteins / adverse effects


  • Insulin
  • Recombinant Proteins
  • Immunoglobulin E