Equipoise and the Dilemma of Randomized Clinical Trials

N Engl J Med. 2011 Feb 3;364(5):476-80. doi: 10.1056/NEJMsb1011301.

MeSH terms

  • Antineoplastic Agents / therapeutic use
  • Dacarbazine / therapeutic use
  • Ethics, Research*
  • Humans
  • Indoles / therapeutic use
  • Melanoma / drug therapy
  • Randomized Controlled Trials as Topic / ethics*
  • Sulfonamides / therapeutic use
  • Therapeutic Equipoise*
  • Treatment Outcome*
  • Uncertainty
  • Vemurafenib

Substances

  • Antineoplastic Agents
  • Indoles
  • Sulfonamides
  • Vemurafenib
  • Dacarbazine