Abstract
The Abbott RealTime HIV-1 viral load assay uses primers and probes targeted to integrase, which is also the target of integrase inhibitors such as raltegravir. Viral loads of 42 raltegravir-susceptible and 40 raltegravir-resistant specimens were determined using RealTime HIV-1 and Roche Monitor (v1.5). The differences in viral load measurements between assays were comparable in the two groups, demonstrating that the RealTime HIV-1 assay can tolerate raltegravir-selected mutations.
Publication types
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Evaluation Study
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Research Support, N.I.H., Extramural
MeSH terms
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Anti-HIV Agents / pharmacology
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Drug Resistance, Viral
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HIV Infections / diagnosis
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HIV Infections / virology*
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HIV Integrase / genetics*
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HIV-1 / genetics
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HIV-1 / isolation & purification*
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Humans
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Molecular Diagnostic Techniques / methods*
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Mutation, Missense*
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Pyrrolidinones / pharmacology
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Raltegravir Potassium
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Reagent Kits, Diagnostic
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Sensitivity and Specificity
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Viral Load / methods*
Substances
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Anti-HIV Agents
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Pyrrolidinones
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Reagent Kits, Diagnostic
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Raltegravir Potassium
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HIV Integrase
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p31 integrase protein, Human immunodeficiency virus 1