Location, location, location: a crystal-clear view of autotaxin saturating LPA receptors

Nat Struct Mol Biol. 2011 Feb;18(2):117-8. doi: 10.1038/nsmb0211-117.

Abstract

The interaction of autotaxin with its substrates leads to the production of lysophosphatidic acids (LPA), bioactive lipids with an emerging prominent role in inflammation and cancer. Two papers in this issue tell the previously unknown story of autotaxin, from substrate discrimination to highly efficient local delivery of LPA to target receptors.

Publication types

  • Comment

MeSH terms

  • Animals
  • Crystallography, X-Ray
  • Integrins / metabolism
  • Lysophospholipids / metabolism*
  • Mice
  • Multienzyme Complexes / chemistry
  • Multienzyme Complexes / metabolism
  • Phosphodiesterase I / chemistry
  • Phosphodiesterase I / metabolism
  • Phosphoric Diester Hydrolases / chemistry
  • Phosphoric Diester Hydrolases / metabolism
  • Pyrophosphatases / chemistry
  • Pyrophosphatases / metabolism
  • Rats
  • Receptors, Lysophosphatidic Acid / metabolism*
  • Substrate Specificity

Substances

  • Integrins
  • Lysophospholipids
  • Multienzyme Complexes
  • Receptors, Lysophosphatidic Acid
  • Phosphoric Diester Hydrolases
  • Phosphodiesterase I
  • alkylglycerophosphoethanolamine phosphodiesterase
  • Pyrophosphatases