TRPP channels and polycystins

Adv Exp Med Biol. 2011;704:287-313. doi: 10.1007/978-94-007-0265-3_16.


The founding member of the TRPP family, TRPP2, was identified as one of the disease genes causing autosomal dominant polycystic kidney disease (ADPKD). ADPKD is the most prevalent, potentially lethal, monogenic disorder in humans, with an average incidence of one in 400 to one in 1,000 individuals worldwide. Here we give an overview of TRPP ion channels and Polycystin-1 receptor proteins focusing on more recent studies. We include the Polycystin-1 family since these proteins are functionally linked to TRPP channels.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Polycystic Kidney, Autosomal Dominant / physiopathology
  • TRPP Cation Channels / physiology*


  • TRPP Cation Channels
  • polycystic kidney disease 1 protein