Ultrasensitivity and positive feedback to promote sharp mitotic entry

Mol Cell. 2011 Feb 4;41(3):243-4. doi: 10.1016/j.molcel.2011.01.016.


In this issue, Trunnell et al. (2011) show that in mitotic entry the positive feedback that drives the activation of cyclin-dependent kinase (Cdk) involves a very ultrasensitive step of phosphorylation of Cdc25C by Cdk, thus strongly contributing to the switch-like behavior of this essential cell-cycle transition.

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