Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

Nature. 1990 Oct 18;347(6294):645-50. doi: 10.1038/347645a0.

Abstract

We have cloned a member of the steroid hormone receptor superfamily of ligand-activated transcription factors. The receptor homologue is activated by a diverse class of rodent hepatocarcinogens that causes proliferation of peroxisomes. Identification of a peroxisome proliferator-activated receptor should help elucidate the mechanism of the hypolipidaemic effect of these hepatocarcinogens and aid evaluation of their potential carcinogenic risk to man.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Binding Sites
  • Cloning, Molecular
  • DNA / metabolism
  • Gene Expression / drug effects
  • Humans
  • Hypolipidemic Agents / adverse effects
  • Hypolipidemic Agents / pharmacology*
  • Liver / ultrastructure*
  • Liver Neoplasms, Experimental / chemically induced
  • Mice
  • Microbodies / drug effects*
  • Microbodies / ultrastructure
  • Molecular Sequence Data
  • Nafenopin / pharmacology
  • Receptors, Estrogen / genetics
  • Receptors, Estrogen / metabolism
  • Receptors, Glucocorticoid / genetics
  • Receptors, Glucocorticoid / metabolism
  • Receptors, Steroid / drug effects
  • Receptors, Steroid / genetics
  • Receptors, Steroid / metabolism*
  • Sequence Homology, Nucleic Acid
  • Tissue Distribution

Substances

  • Hypolipidemic Agents
  • Receptors, Estrogen
  • Receptors, Glucocorticoid
  • Receptors, Steroid
  • Nafenopin
  • DNA

Associated data

  • GENBANK/X57638