Sarcoidosis presenting as transient ischemic attack status

J Stroke Cerebrovasc Dis. 2012 Aug;21(6):515-7. doi: 10.1016/j.jstrokecerebrovasdis.2010.12.003. Epub 2011 Feb 3.


We report a patient who experienced multiple transient ischemic attacks (TIAs) over a 3-month period as the presenting clinical manifestation of sarcoidosis. This previously healthy 27-year-old man was admitted due to several daily episodes of usually left hemiparesis and dysarthria lasting between 15 seconds and 3 minutes. He did not respond to aggressive antithrombotic treatment. Extensive investigations were negative except for a computed tomography body scan showing several small right hilar lymphoadenopathies, which were confirmed by abnormal 67-gallium scintigraphy and 18F-fluorodeoxyglucose positron emission tomography uptakes. The TIA episodes disappeared after the initiation of prednisone therapy. The lymphadenopathy specimens were biopsied via mediastinoscopy, and histological study revealed noncaseating epithelioid granulomatous inflammation consistent with sarcoidosis. Sarcoidosis should be considered in the differential diagnosis of stroke of unknown origin in any young patient, even in the absence of other clinical or laboratory features of sarcoidosis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anticoagulants / therapeutic use
  • Biopsy
  • Central Nervous System Diseases / complications*
  • Central Nervous System Diseases / diagnosis
  • Central Nervous System Diseases / drug therapy
  • Diffusion Magnetic Resonance Imaging
  • Dysarthria / etiology
  • Glucocorticoids / therapeutic use
  • Humans
  • Ischemic Attack, Transient / diagnosis
  • Ischemic Attack, Transient / drug therapy
  • Ischemic Attack, Transient / etiology*
  • Lymphatic Diseases / diagnosis
  • Lymphatic Diseases / etiology
  • Male
  • Paresis / etiology
  • Prednisone / therapeutic use
  • Recurrence
  • Sarcoidosis / complications*
  • Sarcoidosis / diagnosis
  • Sarcoidosis / drug therapy
  • Time Factors
  • Treatment Outcome


  • Anticoagulants
  • Glucocorticoids
  • Prednisone

Supplementary concepts

  • Neurosarcoidosis