Assay validation and diagnostic applications of major acute-phase protein testing in companion animals

Clin Lab Med. 2011 Mar;31(1):51-70. doi: 10.1016/j.cll.2010.10.002. Epub 2010 Dec 3.


The use of major acute-phase proteins (APPs) for assessment of health and disease in companion animals has increased within the last decade because of increased knowledge in the field and increased access to appropriate assay systems for detection of relevant APPs, which are highly species specific. Despite evidence being restricted almost solely to proven excellent overlap performance of these markers in detecting inflammatory activity, clinically relevant studies at higher evidence levels do exist. The available body of literature shows a clear, but seemingly untapped, potential for more extended routine clinical use of major APP testing in companion animal medicine.

Publication types

  • Review

MeSH terms

  • Acute-Phase Proteins / metabolism*
  • Animal Diseases / diagnosis*
  • Animals
  • Blood Chemical Analysis / methods
  • Blood Chemical Analysis / veterinary
  • Cats
  • Cattle
  • Dogs
  • Horses
  • Inflammation / diagnosis
  • Inflammation / veterinary
  • Pets*
  • Predictive Value of Tests
  • Reproducibility of Results
  • Species Specificity
  • Swine
  • Veterinary Medicine / methods


  • Acute-Phase Proteins