Lauroylethanolamide and linoleoylethanolamide improve functional outcome in a rodent model for stroke

Neurosci Lett. 2011 Apr 4;492(3):134-8. doi: 10.1016/j.neulet.2011.01.073. Epub 2011 Feb 4.


Ischemic stroke is a significant health problem affecting over 6 million people in the United States alone. In addition to surgical and thrombolytic therapeutic strategies for stroke, neuroprotective therapies may offer additional benefit. N-acylethanolamines (NAEs) are signaling lipids whose synthesis is upregulated in response to ischemia, suggesting that they may be neuroprotective. To date only three NAEs, arachidonylethanolamide (NAE 20:4), palmitoylethanolamide (NAE 16:0) and oleoylethanolamide (NAE 18:1) have shown to exert neuroprotective effect in animal models for stroke. Here, we describe neuroprotective effects of the hitherto uncharacterized NAEs, lauroylethanolamide (NAE 12:0) and linoleoylethanolamide (NAE 18:2) in a middle cerebral artery occlusion model of stroke. Pretreatment with NAE 18:2 prior to ischemia/reperfusion (I/R) injury resulted in both significantly reduced cortical infarct volume and improved functional outcome as determined using the neurological deficit score. NAE 12:0 improved neurological deficits without a significant reduction lesion size. Our results suggest that NAEs, as a whole, provide neuroprotection during I/R injury and may have therapeutic benefit when used as complementary treatment with other therapies to improve stroke outcome.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Disease Models, Animal
  • Ethanolamines / chemistry
  • Ethanolamines / pharmacology
  • Ethanolamines / therapeutic use*
  • Infarction, Middle Cerebral Artery / drug therapy*
  • Infarction, Middle Cerebral Artery / physiopathology
  • Linoleic Acids
  • Male
  • Neuroprotective Agents / chemistry
  • Neuroprotective Agents / therapeutic use*
  • Polyunsaturated Alkamides
  • Rats
  • Rats, Sprague-Dawley
  • Recovery of Function / physiology*
  • Reperfusion Injury / drug therapy
  • Reperfusion Injury / physiopathology
  • Stroke / drug therapy*
  • Stroke / physiopathology
  • Treatment Outcome


  • Ethanolamines
  • Linoleic Acids
  • N-acylethanolamines
  • Neuroprotective Agents
  • Polyunsaturated Alkamides
  • lauroylethanolamide
  • linoleoyl ethanolamide