Hemophagocytic lymphohistiocytosis associated with precursor B acute lymphoblastic leukemia

Pediatr Blood Cancer. 2011 Apr;56(4):658-60. doi: 10.1002/pbc.22688. Epub 2010 Dec 7.


We report a case of a child with precursor-B acute lymphoblastic leukemia (ALL) who experienced refractory thrombocytopenia and massive splenomegaly during standard induction chemotherapy. He was diagnosed with hemophatocytic lymphohistiocytosis (HLH) during induction. Clinical and laboratory evaluation showed no evidence of infectious cause to HLH. Pancytopenia and HLH persisted after consolidation therapy even with remission from leukemia. After failure to control HLH with ALL-directed therapy and HLH-directed therapy, the patient underwent unrelated donor hematopoietic stem cell transplantation 8 months after diagnosis. He is 34 months post-transplant and in remission from leukemia and HLH.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Humans
  • Lymphohistiocytosis, Hemophagocytic / complications*
  • Lymphohistiocytosis, Hemophagocytic / drug therapy
  • Male
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / complications*
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy