PneumococcaL meningitis in french children before and after the introduction of pneumococcal conjugate vaccine

Pediatr Infect Dis J. 2011 Feb;30(2):168-70. doi: 10.1097/inf.0b013e3181f4cf69.

Abstract

In France, despite a high rate of pneumococcal conjugate vaccine coverage, the number of cases of pneumococcal meningitis in children did not decline significantly between 2001–2002 (n = 264) and 2007–2008 (n = 244). A decline was observed among children < 2 years old (185 [70.1%] to 134 [54.9%] cases; P = 0.0004), but was counterbalanced by an increase among children ≥ 2 years old (79 [29.9%] to 110 [45.1%] cases). Mean age increased significantly, from 2.3 (median 0.8) to 3.8 (median 1.5) years. After pneumococcal conjugate vaccine 7 implementation, a wide diversity of serotypes implicated in pneumococcalmeningitis was observed; serotypes 19A and 7F were the most frequent.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adolescent
  • Bacterial Typing Techniques
  • Child
  • Child, Preschool
  • Female
  • France / epidemiology
  • Heptavalent Pneumococcal Conjugate Vaccine
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Meningitis, Pneumococcal / epidemiology*
  • Meningitis, Pneumococcal / microbiology
  • Meningitis, Pneumococcal / prevention & control*
  • Pneumococcal Vaccines / administration & dosage
  • Pneumococcal Vaccines / immunology*
  • Serotyping
  • Streptococcus pneumoniae / classification
  • Streptococcus pneumoniae / isolation & purification

Substances

  • Heptavalent Pneumococcal Conjugate Vaccine
  • Pneumococcal Vaccines