Three new aaptamines from the marine sponge Aaptos sp. and their proapoptotic properties

Larisa K Shubina; Tatyana N Makarieva; Sergey A Dyshlovoy; Sergey N Fedorov; Pavel S Dmitrenok; Valentin A Stonik

Three new aaptamines from the marine sponge Aaptos sp. and their proapoptotic properties

Nat Prod Commun. 2010 Dec;5(12):1881-4.

Authors

Larisa K Shubina¹, Tatyana N Makarieva, Sergey A Dyshlovoy, Sergey N Fedorov, Pavel S Dmitrenok, Valentin A Stonik

Affiliation

¹ Laboratory of Chemistry MaNaPro, Pacific Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 690022 Vladivostok, Russia.

PMID: 21299112

Abstract

Three new aaptamine-type alkaloids, 2,3-dihydro-2,3-dioxoaaptamine (1), 6-(N-morpholinyl)-4,5-dihydro-5-oxo-demethyl(oxy)aaptamine (2) and 3-(methylamino)demethyl(oxy)aaptamine (3), along with known aaptamines were isolated from the sponge Aaptos sp. Their structures were determined on the basis of detailed analysis of their 1D and 2D NMR spectroscopic and mass spectral data. The isolated compounds induced apoptosis in human leukemia THP-1 cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / isolation & purification*
Alkaloids / pharmacology
Animals
Apoptosis / drug effects*
Cell Line
Humans
Magnetic Resonance Spectroscopy
Naphthyridines / chemistry
Naphthyridines / isolation & purification*
Naphthyridines / pharmacology
Porifera / chemistry*

Substances

Alkaloids
Naphthyridines
aaptamine