The Aurora A F31I polymorphism is not a risk factor for glioblastoma

World Neurosurg. 2010 Jul;74(1):144-6. doi: 10.1016/j.wneu.2010.04.003.

Abstract

Background: The Aurora A F31I polymorphism has been linked to increased risk of several human cancers. Glioblastoma (GBM) is the most malignant glioma as well as the most frequent adult primary brain tumor.

Methods: In this case-control study we investigated the association of Aurora A F31I polymorphism with GBM risk.

Results: A total of 96 histologically confirmed patients with GBM and 93 health individuals were analyzed for the Aurora A F31I single nucleotide polymorphism. The single nucleotide polymorphism data were compared and risks associated with individual genotypes and allelotypes were evaluated in terms of odd ratios.

Conclusions: The data obtained from this case-control study demonstrates that the Aurora A F31I polymorphism is not a significant risk for GBMs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles*
  • Aurora Kinases
  • Brain Neoplasms / genetics*
  • Case-Control Studies
  • Female
  • Gene Frequency / genetics
  • Genetic Predisposition to Disease / genetics
  • Genotype
  • Glioblastoma / genetics*
  • Humans
  • Male
  • Polymorphism, Genetic / genetics*
  • Polymorphism, Single Nucleotide / genetics
  • Protein Serine-Threonine Kinases / genetics*
  • Reference Values

Substances

  • Aurora Kinases
  • Protein Serine-Threonine Kinases