Erythrocyte membrane phospholipid polyunsaturated fatty acids are related to plasma C-reactive protein and adiponectin in middle-aged German women and men

Eur J Nutr. 2011 Dec;50(8):625-36. doi: 10.1007/s00394-011-0169-4. Epub 2011 Feb 8.

Abstract

Purpose: Modulation of circulating inflammatory markers and adiponectin may link PUFA to risk of diabetes and cardiovascular diseases. We investigated erythrocyte n-6 and n-3 PUFA in relation to plasma C-reactive protein (CRP) and adiponectin, and whether the Pro12Ala polymorphism in the PPARγ2 gene (PPARG2) modified these associations.

Methods: We conducted a cross-sectional analysis among 1,222 women and 758 men participating in the EPIC-Potsdam study.

Results: Most notably, in both sexes, higher linoleic acid (LA) was related to lower CRP (geometric mean outcome [mg/L], quintile 1, quintile 5, p for trend ≤ 0.01 unless otherwise stated: 0.95, 0.61 [women], 0.67, 0.51 [men]) and higher adiponectin (7.9, 9.1 [women], 5.3, 6.1 [men]), whereas higher γ-linolenic acid (GLA) and dihomo-γ-linolenic acid (DGLA) were related to higher CRP (GLA: 0.63, 0.92 [women], 0.55, 0.70, p = 0.08 [men], DGLA: 0.55, 1.07 [women], 0.52, 0.76 [men]) and lower adiponectin (GLA: 8.6, 8.0 [women], 5.8, 5.4, p = 0.08 [men], DGLA: 9.2, 7.9 [women], 5.9, 5.4, p = 0.08 [men]) adjusting for age and lifestyle. The associations mostly did neither strongly nor significantly vary by PPARG2 genotype. In women, Pro12Ala appeared to interact with arachidonic acid on CRP (p = 0.04), as well as with docosatetraenoic acid on CRP (p = 0.08) and adiponectin (p = 0.02).

Conclusions: Our findings suggest that erythrocyte PUFA, particularly LA and n-6 higher unsaturated fatty acids, are related to circulating CRP and adiponectin. They do not indicate that PUFA strongly interact with the PPARG2 Pro12Ala variant on these risk markers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 8,11,14-Eicosatrienoic Acid / blood*
  • Adiponectin / blood*
  • Adult
  • Biomarkers
  • C-Reactive Protein / metabolism*
  • Cross-Sectional Studies
  • Erythrocyte Membrane / chemistry*
  • European Continental Ancestry Group
  • Female
  • Germany
  • Humans
  • Male
  • Middle Aged
  • PPAR gamma / genetics
  • PPAR gamma / metabolism
  • Phospholipids / blood*
  • Polymorphism, Genetic
  • Risk Factors
  • gamma-Linolenic Acid / blood*

Substances

  • Adiponectin
  • Biomarkers
  • PPAR gamma
  • Phospholipids
  • gamma-Linolenic Acid
  • C-Reactive Protein
  • 8,11,14-Eicosatrienoic Acid