Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice

Immunogenetics. 1978 Dec;7(1):17-24. doi: 10.1007/BF01843983.


The unresponsiveness to LPS detected in C57BL/10Cr mice is inherited as a recessive trait and is determined by an autosomal gene linked to theMup-1 locus on chromosome 4. Since no complementation for LPS responsiveness was observed in F(1) hybrid mice between C3H/HeJ and C57BL/10Cr, we conclude that C57BL/10Cr mice carry a defective allele at the sameLps locus, previously identified by the mutation detected in the C3H/HeJ strain.