Hypoxia-inducible factors--regulation, role and comparative aspects in tumourigenesis

Vet Comp Oncol. 2011 Mar;9(1):16-37. doi: 10.1111/j.1476-5829.2010.00233.x. Epub 2010 Aug 16.


Hypoxia-inducible factors (HIFs) play a key role in the cellular response experienced in hypoxic tumours, mediating adaptive responses that allow hypoxic cells to survive in the hostile environment. Identification and understanding of tumour hypoxia and the influence on cellular processes carries important prognostic information and may help identify potential hypoxia circumventing and targeting strategies. This review summarizes current knowledge on HIF regulation and function in tumour cells and discusses the aspects of using companion animals as comparative spontaneous cancer models. Spontaneous tumours in companion animals hold a great research potential for the evaluation and understanding of tumour hypoxia and in the development of hypoxia-targeting therapeutics.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Basic Helix-Loop-Helix Transcription Factors / chemistry
  • Basic Helix-Loop-Helix Transcription Factors / genetics
  • Basic Helix-Loop-Helix Transcription Factors / metabolism*
  • Cat Diseases / pathology*
  • Cats
  • Cell Hypoxia
  • Disease Models, Animal*
  • Dog Diseases / pathology*
  • Dogs
  • Hypoxia-Inducible Factor 1 / chemistry
  • Hypoxia-Inducible Factor 1 / genetics
  • Hypoxia-Inducible Factor 1 / metabolism
  • MicroRNAs / metabolism
  • Neoplasms / pathology*
  • Neoplasms / veterinary*
  • Neoplastic Stem Cells / pathology


  • Basic Helix-Loop-Helix Transcription Factors
  • Hypoxia-Inducible Factor 1
  • MicroRNAs
  • endothelial PAS domain-containing protein 1