Protein scaffolds in the coupling of synaptic exocytosis and endocytosis

Nat Rev Neurosci. 2011 Mar;12(3):127-38. doi: 10.1038/nrn2948. Epub 2011 Feb 9.


Mechanisms that ensure robust long-term performance of synaptic transmission over a wide range of activity are crucial for the integrity of neuronal networks, for processing sensory information and for the ability to learn and store memories. Recent experiments have revealed that such robust performance requires a tight coupling between exocytic vesicle fusion at defined release sites and endocytic retrieval of synaptic vesicle membranes. Distinct presynaptic scaffolding proteins are essential for fulfilling this requirement, providing either ultrastructural coordination or acting as signalling hubs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Endocytosis / physiology*
  • Exocytosis / physiology*
  • Humans
  • Matrix Attachment Regions / physiology*
  • Synapses / physiology*
  • Synapses / ultrastructure
  • Synaptic Transmission / physiology
  • Synaptic Vesicles / physiology
  • Synaptic Vesicles / ultrastructure