Identification of regions of positive selection using Shared Genomic Segment analysis

Eur J Hum Genet. 2011 Jun;19(6):667-71. doi: 10.1038/ejhg.2010.257. Epub 2011 Feb 9.

Abstract

We applied a shared genomic segment (SGS) analysis, incorporating an error model, to identify complete, or near complete, selective sweeps in the HapMap phase II data sets. This method is based on detecting heterozygous sharing across all individuals within a population, to identify regions of sharing with at least one allele in common. We identified multiple interesting regions, many of which are concordant with positive selection regions detected by previous population genetic tests. Others are suggested to be novel regions. Our finding illustrates the utility of SGS as a method for identifying regions of selection, and some of these regions have been proposed to be candidate regions for harboring disease genes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Algorithms
  • Databases, Genetic
  • Gene Frequency
  • Genetic Variation*
  • Genetics, Population / methods*
  • Genetics, Population / statistics & numerical data
  • Genome, Human
  • Genomics / methods*
  • Haplotypes
  • Heterozygote
  • Humans
  • Models, Genetic
  • Population Groups / genetics*
  • Sample Size
  • Selection, Genetic*
  • Software