Common variants near TERC are associated with leukocyte telomere length in the Chinese Han population

Eur J Hum Genet. 2011 Jun;19(6):721-3. doi: 10.1038/ejhg.2011.4. Epub 2011 Feb 9.

Abstract

A recent genome-wide association study has identified an association between leukocyte telomere length (LTL) and a locus at 3q26 that includes TERC. In order to evaluate the effects of the SNPs rs12696304 and rs16847897 near TERC in the population of mainland China, we conducted an association study of LTL focusing on these two candidate SNPs in a sample of 4016 Chinese Han individuals. Multiple linear regression analyses were performed to evaluate the association of LTL with each SNP adjusted for age, gender and diabetes status. In the study, we confirmed the association of SNP rs12696304 and rs16847897 near TERC with LTL in the Chinese Han population (P ∼ 4.5 × 10(-3) and 9.5 × 10(-5), respectively). Each copy of the major allele of rs12696304 and rs16847897 was associated with a shorter mean telomere length of 0.024 and 0.031 T/S respectively, which is equivalent to about 3 and 4 years of average age-related telomere attrition. Our short report confirmed the effects of SNPs near TERC on LTL in the Chinese Han population for the first time.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Aged
  • Alleles
  • Asian Continental Ancestry Group / genetics*
  • Case-Control Studies
  • China
  • DNA Fingerprinting
  • Diabetes Mellitus / epidemiology
  • Diabetes Mellitus / genetics*
  • Female
  • Gene Dosage
  • Genome-Wide Association Study / methods*
  • Genotype
  • Humans
  • Leukocytes / chemistry*
  • Leukocytes / cytology
  • Linear Models
  • Longevity / genetics
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Sex Factors
  • Telomerase / genetics*
  • Telomere / chemistry*
  • Telomere / genetics

Substances

  • Telomerase