Initial impact of the sequencing of the human genome

Nature. 2011 Feb 10;470(7333):187-97. doi: 10.1038/nature09792.


The sequence of the human genome has dramatically accelerated biomedical research. Here I explore its impact, in the decade since its publication, on our understanding of the biological functions encoded in the genome, on the biological basis of inherited diseases and cancer, and on the evolution and history of the human species. I also discuss the road ahead in fulfilling the promise of genomics for medicine.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Evolution, Molecular
  • Genetic Predisposition to Disease / genetics*
  • Genetics, Medical* / trends
  • Genome, Human / genetics*
  • History, 21st Century
  • Human Genome Project* / history
  • Humans
  • Polymorphism, Genetic / genetics
  • Sequence Analysis, DNA / history