UVB: susceptibility in malignant melanoma

An Bras Dermatol. 2010 Nov-Dec;85(6):843-8. doi: 10.1590/s0365-05962010000600010.
[Article in English, Portuguese]

Abstract

Background: It is well established that UV radiation provokes an immunological depletion in the skin, enabling the development of malignant cutaneous tumors. Most nonmelanoma skin cancer patients are considered to be UVB-susceptible.

Objective: To study the behavior of UVB- susceptibility in malignant melanoma (MM) patients and whether this is a risk factor to the development of MM.

Methods: Eighty-eight volunteers were selected and divided into two groups: healthy control group (n = 61) and MM group (n = 27), which were identified according to the following clinical criteria: histopathological type, level of invasion, skin phototype, sex and age. Susceptibility to ultraviolet B (UVB) radiation was measured by the onset of a contact hypersensitivity reaction to diphenylcyclopropenone among individuals sensitized in previously irradiated areas.

Results: Susceptibility to UVB radiation was 81.5 in the MM group and 31.2% in the control group. The risk of an UVB-susceptible individual to develop MM was 9.7 times higher than when UVB resistant.

Conclusion: UVB susceptibility should be considered an important risk factor to the development of this type of cancer.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Case-Control Studies
  • Disease Susceptibility
  • Dose-Response Relationship, Radiation
  • Female
  • Humans
  • Male
  • Melanoma / etiology*
  • Middle Aged
  • Neoplasms, Radiation-Induced / etiology*
  • Risk Factors
  • Skin Neoplasms / etiology*
  • Ultraviolet Rays / adverse effects*
  • Young Adult