[TINU syndrome and lymphoid interstitial alveolitis: a new observation]

Tunis Med. 2011 Feb;89(2):210-2.
[Article in French]

Abstract

Background: TINU syndrome is a rare entity known Dobrin disease, combining uveitis mostly bilateral and recurrent with acute tubulo interstitial nephritis (AIN) occurring in young adults. The etiology and pathogenesis of this syndrome remain unknown.

Aim: To report a new case of TINU syndrome and to discuss its etiopathogenesis.

Case report: This 33 year old women is hospitalized for exploration of acute renal failure, in a context of deterioration of general condition, associated with a unilateral anterior uveitis. The bronchoalveolar lavage showed lymphoid interstitial alveolitis with CD4 and the renal biopsy found lesions characteristic of AIN. Evolution under corticoïd treatment was favorable.

Conclusion: Lymphoid interstitial alveolitis associated with TINU syndrome has been reported only twice before. The discovery of a TINU syndrome must practice bronchoalveolar lavage in search of sub clinical pulmonary involvement.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Acute Kidney Injury / etiology
  • Adult
  • Bronchoalveolar Lavage Fluid / cytology
  • Female
  • Humans
  • Lung Diseases, Interstitial / complications*
  • Lung Diseases, Interstitial / pathology
  • Nephritis, Interstitial / complications*
  • Syndrome
  • Uveitis / complications