Factors regulating the induction of ornithine decarboxylase in fetal rat liver cells in culture

Biochim Biophys Acta. 1978 Sep 21;543(1):10-5. doi: 10.1016/0304-4165(78)90449-x.


Various hormonal and non-hormonal agents were tested for their ability to induce ornithine decarboxylase (EC in primary cultures of fetal rat liver cells that retain many of the differentiated functions of hepatocytes. The only agents to induce ornithine decarboxylase in this cell type were fetal calf serum, prostaglandin E1 and cyclic AMP derivatives. Also, the amino acid arginine would induce ornithine decarboxylase in this cell type following arginine starvation for 24 h. These observations are in contrast to the wide range of hormones, e.g. insulin, hydrocortisone, glucagon and growth hormone, than can induce ornithine decarboxylase in vivo in the adult rat liver but which are all without effect on fetal rat liver cells.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Bucladesine / pharmacology
  • Carboxy-Lyases / biosynthesis*
  • Cells, Cultured
  • Culture Media
  • Enzyme Induction / drug effects
  • Fetus
  • Liver / embryology
  • Liver / enzymology*
  • Ornithine Decarboxylase / biosynthesis*
  • Prostaglandins E / pharmacology
  • Rats


  • Culture Media
  • Prostaglandins E
  • Bucladesine
  • Carboxy-Lyases
  • Ornithine Decarboxylase