Effect of plastoquinone derivative 10-(6'-plastoquinonyl)decyltriphenylphosphonium (SkQ1) on contents of steroid hormones and NO level in rats

Biochemistry (Mosc). 2010 Nov;75(11):1383-7. doi: 10.1134/s0006297910110106.

Abstract

Introduction of the plastoquinone derivative 10-(6'-plastoquinonyl)decyltriphenylphosphonium (SkQ1) into male Wistar rats once a day for two weeks in doses of 25 and 250 nmol/kg led to elevation of 17β-estradiol level in blood serum by 33 and 41%, respectively. At the same time, nitrate and nitrite contents in the rat blood serum increased by 49 and 34%, respectively. ESR spectroscopy with diethyldithiocarbamateiron complex as a spin trap showed more than twofold increase in NO production in lungs, but not in blood, liver, and intestines, following the SkQ1 daily introduction at a dose of 25 nmol/kg.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / pharmacology*
  • Estradiol / biosynthesis*
  • Estradiol / blood
  • Hydrocortisone / blood
  • Intestinal Mucosa / metabolism
  • Intestines / drug effects
  • Liver / drug effects
  • Liver / metabolism
  • Lung / drug effects
  • Lung / metabolism
  • Male
  • Nitric Oxide / biosynthesis*
  • Nitric Oxide / blood
  • Plastoquinone / analogs & derivatives*
  • Plastoquinone / pharmacology
  • Progesterone / blood
  • Rats
  • Rats, Wistar
  • Testosterone / blood

Substances

  • 10-(6'-plastoquinonyl)decyltriphenylphosphonium
  • Antioxidants
  • Nitric Oxide
  • Testosterone
  • Progesterone
  • Estradiol
  • Plastoquinone
  • Hydrocortisone