Abstract
Some esters of 7-theophyllinylacetic acid were synthetized, characterized physicochemically and tested for their anti-inflammatory properties. As compared to indomethacin, reference anti-inflammatory drug, all synthetized compounds were less toxic. The anti-inflammatory properties are influenced by the nature of the ester group radicals, the more active having ramified alchils.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Anti-Inflammatory Agents, Non-Steroidal / toxicity
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Carrageenan
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Drug Evaluation, Preclinical
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Edema / chemically induced
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Edema / drug therapy
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Esters / chemical synthesis
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Esters / therapeutic use
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Esters / toxicity
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Indomethacin / toxicity
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Mice
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Rats
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Structure-Activity Relationship
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Theophylline / analogs & derivatives*
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Theophylline / chemical synthesis
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Theophylline / therapeutic use
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Theophylline / toxicity
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Esters
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Carrageenan
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Theophylline
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acefylline
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Indomethacin