Temporal dynamics of cerebrospinal fluid anti-aquaporin-4 antibodies in patients with neuromyelitis optica spectrum disorders

J Neuroimmunol. 2011 May;234(1-2):124-30. doi: 10.1016/j.jneuroim.2011.01.007. Epub 2011 Feb 11.


Neuromyelitis optica spectrum disorders (NMOSD) are associated with anti-aquaporin-4 autoantibodies (AQP4-IgG). Limited data is available on longitudinal cerebrospinal fluid (CSF) AQP4-IgG and their relation to disease activity and inflammatory parameters. AQP4-IgG titers were measured in matched longitudinal serum and CSF samples of 12 patients with NMOSD by an immunofluorescence assay and correlated with clinical parameters. CSF AQP4-IgG were present in patients with high serum titers and correlated with spinal MRI lesion length and CSF parameters. Clinical improvement was associated with a decrease in CSF, but not serum, AQP4-IgG titers. Thus, CSF AQP4-IgG were associated with clinical activity and neuroinflammation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aquaporin 4 / immunology*
  • Cell Count / methods
  • Cell Line, Transformed
  • Female
  • Follow-Up Studies
  • Humans
  • Immunoglobulin G / blood
  • Immunoglobulin G / cerebrospinal fluid*
  • Male
  • Middle Aged
  • Neuromyelitis Optica / blood
  • Neuromyelitis Optica / cerebrospinal fluid*
  • Nonlinear Dynamics*
  • Young Adult


  • AQP4 protein, human
  • Aquaporin 4
  • Immunoglobulin G