Phytochemical potential of Eruca sativa for inhibition of melanoma tumor growth

Fitoterapia. 2011 Jun;82(4):647-53. doi: 10.1016/j.fitote.2011.02.004. Epub 2011 Feb 21.


Solvent extracts from the aerial and root parts and seed oil from E. sativa (rocket salad) were assayed for anticancer activity against melanoma cells. The seed oil (isothiocyanates rich) significantly (p<0.01) reduced the tumor growth comparable to the control. Remarkably, the seed oil inhibited melanoma growth and angiogenesis in mice without any major toxicity. The findings qualify seed oil for further investigations in the real of cancer prevention and treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / analysis*
  • Antineoplastic Agents, Phytogenic / therapeutic use
  • Brassicaceae / chemistry*
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Humans
  • Isothiocyanates / analysis
  • Melanoma, Experimental / drug therapy*
  • Mice
  • Phenols / analysis
  • Phytosterols / analysis
  • Phytotherapy*
  • Plant Oils / chemistry
  • Plant Oils / therapeutic use*
  • Seeds / chemistry


  • Antineoplastic Agents, Phytogenic
  • Isothiocyanates
  • Phenols
  • Phytosterols
  • Plant Oils