PARP inhibitors in cancer therapy: promise, progress, and puzzles

Cancer Cell. 2011 Feb 15;19(2):165-7. doi: 10.1016/j.ccr.2011.01.047.


A recent article in the New England Journal of Medicine by O'Shaughnessy et al. provides evidence that a treatment strategy aimed at inducing DNA damage with chemotherapy while simultaneously disabling repair using a PARP inhibitor might offer hope for patients with a treatment-refractory form of breast cancer.

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