Nonreplication of an association of SGIP1 SNPs with alcohol dependence and resting theta EEG power

Psychiatr Genet. 2011 Oct;21(5):265-6. doi: 10.1097/YPG.0b013e32834371fd.

Abstract

A recent study in a sample of Plains Indians showed association between eight single nucleotide polymorphisms (SNPs) located in the SGIP1 gene and resting θ electroencephalogram (EEG) power. This association appeared to generalize to alcohol use disorders, for which EEG power is a potential endophenotype. We analyzed a large, diverse sample for replication of the association of these implicated SGIP1 SNPs (genotyped on the Illumina 1M platform) with alcohol dependence (N=3988) and θ EEG power (N=1066). We found no evidence of association of the earlier implicated SGIP1 SNPs with either alcohol dependence or θ EEG power (all P>0.15) in this sample. The earlier implicated SNPs located in SGIP1 gene showed no association with alcohol dependence or θ EEG power in this sample of individuals with European and/or African ancestry. This failure to replicate may be the result of differences in ancestry between this sample and the original sample.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Alcoholism / genetics*
  • Alcoholism / physiopathology*
  • Carrier Proteins / genetics*
  • Electroencephalography*
  • Genetic Association Studies*
  • Genetic Predisposition to Disease
  • Humans
  • Membrane Proteins
  • Polymorphism, Single Nucleotide / genetics*
  • Reproducibility of Results
  • Rest / physiology*

Substances

  • Adaptor Proteins, Signal Transducing
  • Carrier Proteins
  • Membrane Proteins
  • SGIP1 protein, human