Midterm results of low-dose intravitreal triamcinolone as adjunctive treatment for proliferative vitreoretinopathy

Retina. 2011 Jun;31(6):1137-42. doi: 10.1097/IAE.0b013e3181fe5427.


Purpose: To evaluate the midterm anatomical and functional outcomes of intravitreal injection of low-dose triamcinolone acetonide in silicone oil-filled eyes as an adjunctive treatment for proliferative vitreoretinopathy.

Methods: This is a retrospective interventional case series. Patients with proliferative vitreoretinopathy grade C or D received pars plana vitrectomy combined with silicone oil tamponade and intravitreal injection of 2 mg of triamcinolone acetonide in the first stage and silicone oil removal in the second stage. Primary outcome measures were retinal reattachment rate and best-corrected visual acuity.

Results: In all, 37 eyes from 37 patients were included in this study. The mean follow-up duration was 22.9 ± 9.6 months. Retina was reattached in 36 (97.3%) eyes at the last visit. The mean best-corrected visual acuity was 1.76 ± 0.56 logMAR at baseline, which improved to 0.87 ± 0.60 logMAR at the last visit (P < 0.001). Best-corrected visual acuity increased in 31 (83.8%) eyes, remained unchanged in 5 (13.5%) eyes, and decreased in 1 (2.7%) eye at last visit compared with baseline.

Conclusion: Low-dose (2 mg) triamcinolone acetonide intravitreal injection as an adjunct to vitrectomy and silicone oil tamponade in treating proliferative vitreoretinopathy (grade C or D) appears to be effective and safe.

MeSH terms

  • Adult
  • Aged
  • Drainage / methods
  • Endotamponade*
  • Female
  • Glucocorticoids / administration & dosage*
  • Humans
  • Intravitreal Injections
  • Laser Coagulation
  • Lens Implantation, Intraocular
  • Male
  • Middle Aged
  • Phacoemulsification
  • Retrospective Studies
  • Silicone Oils / administration & dosage*
  • Treatment Outcome
  • Triamcinolone Acetonide / administration & dosage*
  • Visual Acuity / physiology
  • Vitrectomy*
  • Vitreoretinopathy, Proliferative / drug therapy
  • Vitreoretinopathy, Proliferative / surgery
  • Vitreoretinopathy, Proliferative / therapy*
  • Vitreous Body
  • Young Adult


  • Glucocorticoids
  • Silicone Oils
  • Triamcinolone Acetonide