The myogenic transcriptional network

Cell Mol Life Sci. 2011 Jun;68(11):1843-9. doi: 10.1007/s00018-011-0629-2. Epub 2011 Feb 12.


Myogenesis has been a leading model for elucidating the molecular mechanisms that underlie tissue differentiation and development since the discovery of MyoD. During myogenesis, the fate of myogenic precursor cells is first determined by Pax3/Pax7. This is followed by regulation of the myogenic differentiation program by muscle regulatory factors (Myf5, MyoD, Myog, and Mrf4) to form muscle tissues. Recent studies have uncovered a detailed myogenic program that involves the RP58 (Zfp238)-dependent regulatory network, which is critical for repressing the expression of inhibitor of DNA binding (Id) proteins. These novel findings contribute to a comprehensive understanding of the muscle differentiation transcriptional program.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Gene Regulatory Networks / physiology*
  • Humans
  • Models, Biological
  • Muscle Development*
  • MyoD Protein / metabolism
  • PAX3 Transcription Factor
  • PAX7 Transcription Factor / metabolism
  • Paired Box Transcription Factors / metabolism


  • MyoD Protein
  • PAX3 Transcription Factor
  • PAX3 protein, human
  • PAX7 Transcription Factor
  • PAX7 protein, human
  • Paired Box Transcription Factors