Effect of the herbal medicine dai-kenchu-to on gastrointestinal motility in patients with megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS) and chronic idiopathic intestinal pseudo-obstruction (CIIP): report of two cases

Tokai J Exp Clin Med. 2009 Apr 20;34(1):28-33.


Dai-kenchu-to (DKT), a traditional Japanese herbal medicine (Kampo medicine), composed of zanthoxylum fruit, ginseng root, dried ginger rhizome and malt sugar, is clinically effective for postoperative ileus and chronic constipation. MMIHS and CIIP are severe motility disorder associated with high morbidity. The aim of this study was to evaluate the effect of DKT on functional intestinal obstruction. DKT was clinically effective for gastrointestinal motility in a case with MMIHS, but not effective in one with CIIP. MMIHS and CIIP are speculated to have different pathogenesis regarding gastrointestinal pseudo-obstruction based upon the effect of this drug.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Multiple / drug therapy
  • Abnormalities, Multiple / pathology
  • Colon / abnormalities
  • Colon / pathology
  • Female
  • Gastrointestinal Motility / drug effects*
  • Genetic Diseases, X-Linked / drug therapy
  • Genetic Diseases, X-Linked / pathology
  • Humans
  • Infant
  • Intestinal Pseudo-Obstruction / congenital
  • Intestinal Pseudo-Obstruction / drug therapy
  • Intestinal Pseudo-Obstruction / pathology
  • Medicine, East Asian Traditional
  • Panax
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use*
  • Urinary Bladder / abnormalities
  • Urinary Bladder / pathology
  • Young Adult
  • Zanthoxylum
  • Zingiberaceae


  • Plant Extracts
  • dai-kenchu-to

Supplementary concepts

  • Congenital idiopathic intestinal pseudoobstruction
  • Megacystis microcolon intestinal hypoperistalsis syndrome