The effect of intraperitoneally administered dimethyl sulfoxide on absence-like epileptic activity of freely moving WAG/Rij rats

Zsolt Kovács; András Czurkó; Katalin A Kékesi; Gábor Juhász

doi:10.1016/j.jneumeth.2011.02.005

The effect of intraperitoneally administered dimethyl sulfoxide on absence-like epileptic activity of freely moving WAG/Rij rats

J Neurosci Methods. 2011 Apr 15;197(1):133-6. doi: 10.1016/j.jneumeth.2011.02.005. Epub 2011 Feb 12.

Authors

Zsolt Kovács¹, András Czurkó, Katalin A Kékesi, Gábor Juhász

Affiliation

¹ Department of Zoology, University of West Hungary, Savaria Campus, Károlyi Gáspár tér 4., 9700 Szombathely, Hungary. zskovacs@ttk.nyme.hu

PMID: 21320528
DOI: 10.1016/j.jneumeth.2011.02.005

Abstract

Dimethyl sulfoxide (DMSO) is a widely used solvent for water-insoluble molecules and it has antioxidant, neuroprotective and cryopreservative effects. While DMSO is a regularly used solvent in research and a therapeutic agent, several cases of DMSO evoked seizures were reported in the literature. Therefore, we investigated the effect of different doses of DMSO on the absence-like epileptic activity of Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. We revealed that low doses of DMSO decreased whereas high doses of DMSO increased the absence-like epileptic activity of WAG/Rij rats.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Action Potentials / drug effects*
Action Potentials / physiology
Animals
Dimethyl Sulfoxide / administration & dosage
Dimethyl Sulfoxide / pharmacology*
Disease Models, Animal
Epilepsy, Absence / chemically induced*
Epilepsy, Absence / drug therapy*
Epilepsy, Absence / pathology
Male
Movement / drug effects
Movement / physiology
Neurons / drug effects
Neurons / physiology
Rats
Rats, Inbred Strains

Substances

Dimethyl Sulfoxide