CNK1 and other scaffolds for Akt/FoxO signaling

Biochim Biophys Acta. 2011 Nov;1813(11):1971-7. doi: 10.1016/j.bbamcr.2011.02.008. Epub 2011 Feb 12.


FoxO transcription factors mediate anti-proliferative and pro-apoptotic signals and act as tumor suppressors in cancer. Posttranslational modifications including phosphorylation and acetylation regulate FoxO activity by a cytoplasmic-nuclear shuttle mechanism. Scaffold proteins coordinating signaling pathways in time and space play a critical role in this process. CNK1 acts as a scaffold protein in several signaling pathways controlling the function of FoxO proteins. An understanding of CNK1 and other scaffolds in the FoxO signaling network will provide insights how to release the tumor suppressor function of FoxO as a possibility to block oncogenic pathways. This article is part of a Special Issue entitled: P13K-AKT-FoxO axis in cancer and aging.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Forkhead Box Protein O1
  • Forkhead Transcription Factors / metabolism*
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Models, Biological
  • Proto-Oncogene Proteins c-akt / metabolism*
  • Signal Transduction*


  • CNKSR1 protein, human
  • FOXO1 protein, human
  • Forkhead Box Protein O1
  • Forkhead Transcription Factors
  • Intracellular Signaling Peptides and Proteins
  • Proto-Oncogene Proteins c-akt