Ivermectin, 'wonder drug' from Japan: the human use perspective

Proc Jpn Acad Ser B Phys Biol Sci. 2011;87(2):13-28. doi: 10.2183/pjab.87.13.


Discovered in the late-1970s, the pioneering drug ivermectin, a dihydro derivative of avermectin--originating solely from a single microorganism isolated at the Kitasato Institute, Tokyo, Japan from Japanese soil--has had an immeasurably beneficial impact in improving the lives and welfare of billions of people throughout the world. Originally introduced as a veterinary drug, it kills a wide range of internal and external parasites in commercial livestock and companion animals. It was quickly discovered to be ideal in combating two of the world's most devastating and disfiguring diseases which have plagued the world's poor throughout the tropics for centuries. It is now being used free-of-charge as the sole tool in campaigns to eliminate both diseases globally. It has also been used to successfully overcome several other human diseases and new uses for it are continually being found. This paper looks in depth at the events surrounding ivermectin's passage from being a huge success in Animal Health into its widespread use in humans, a development which has led many to describe it as a "wonder" drug.

Publication types

  • Review

MeSH terms

  • Antiparasitic Agents / chemistry
  • Antiparasitic Agents / pharmacology
  • Antiparasitic Agents / therapeutic use
  • Drug Resistance / drug effects
  • Humans
  • Ivermectin / chemistry
  • Ivermectin / pharmacology
  • Ivermectin / therapeutic use*
  • Japan
  • Onchocerciasis / drug therapy
  • Treatment Outcome


  • Antiparasitic Agents
  • Ivermectin