Screening for retinopathy of prematurity in a tertiary hospital in Istanbul: incidence and risk factors

J Pediatr Ophthalmol Strabismus. Jan-Feb 2012;49(1):21-5. doi: 10.3928/01913913-20110208-01. Epub 2011 Feb 15.


Purpose: To study the incidence and risk factors of retinopathy of prematurity (ROP) in premature infants examined in a tertiary hospital in Istanbul.

Methods: Data of infants screened for ROP from April 2007 to September 2009 were retrospectively reviewed. Possible risk factors and eye examinations were recorded and analyzed using the chi-square test and univariate and multivariate regressions.

Results: ROP was detected in 177 (34.3%) of the 517 infants enrolled in the study; 64 had mild ROP (77.4%) and 38 had severe ROP (22.6%). The mean gestational age and birth weight of patients who were treated for ROP were 28.6 ± 2.3 and 1,143.5 ± 337.4, respectively. Two of these infants had a gestational age of 32 g or greater and three had a birth weight of 1,500 g or greater. The multivariate regression analyses showed gestational age, birth weight, sepsis, respiratory distress syndrome, and length of oxygen therapy as independent predictors of ROP.

Conclusion: The incidence of ROP observed in this study was higher than that in developed countries and relatively more mature infants were affected. Criteria including gestational age of less than 34 weeks or birth weight of less than 2,000 g would have identified all infants who were at risk.

MeSH terms

  • Birth Weight
  • Female
  • Gestational Age
  • Humans
  • Incidence
  • Infant
  • Infant, Newborn
  • Infant, Premature
  • Male
  • Oxygen Inhalation Therapy
  • Retinopathy of Prematurity / diagnosis*
  • Retinopathy of Prematurity / epidemiology*
  • Retrospective Studies
  • Risk Factors
  • Tertiary Care Centers / statistics & numerical data*
  • Turkey / epidemiology