Infection with human coronavirus NL63 enhances streptococcal adherence to epithelial cells

J Gen Virol. 2011 Jun;92(Pt 6):1358-1368. doi: 10.1099/vir.0.028381-0. Epub 2011 Feb 16.


Understanding the mechanisms of augmented bacterial pathogenicity in post-viral infections is the first step in the development of an effective therapy. This study assessed the effect of human coronavirus NL63 (HCoV-NL63) on the adherence of bacterial pathogens associated with respiratory tract illnesses. It was shown that HCoV-NL63 infection resulted in an increased adherence of Streptococcus pneumoniae to virus-infected cell lines and fully differentiated primary human airway epithelium cultures. The enhanced binding of bacteria correlated with an increased expression level of the platelet-activating factor receptor (PAF-R), but detailed evaluation of the bacterium-PAF-R interaction revealed a limited relevance of this process.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Adhesion*
  • Cell Line
  • Cells, Cultured
  • Coronavirus NL63, Human / physiology*
  • Epithelial Cells / metabolism
  • Epithelial Cells / microbiology*
  • Epithelial Cells / virology*
  • Gene Expression
  • Humans
  • Platelet Membrane Glycoproteins / genetics
  • Platelet Membrane Glycoproteins / metabolism
  • Receptors, G-Protein-Coupled / genetics
  • Receptors, G-Protein-Coupled / metabolism
  • Respiratory Tract Infections / genetics
  • Respiratory Tract Infections / metabolism
  • Respiratory Tract Infections / microbiology*
  • Respiratory Tract Infections / virology*
  • Streptococcus / physiology*


  • Platelet Membrane Glycoproteins
  • Receptors, G-Protein-Coupled
  • platelet activating factor receptor