Computational approaches to studying thrombus development

Arterioscler Thromb Vasc Biol. 2011 Mar;31(3):500-5. doi: 10.1161/ATVBAHA.110.213397.


In addition to descriptive biological models, many computational models have been developed for hemostasis/thrombosis that provide quantitative characterization of thrombus development. Simulations using computational models that have been developed for coagulation reactions, platelet activation, and fibrinogen assembly have been shown to be in close agreement with experimental data. Models of processes involved in hemostasis/thrombosis are being integrated to simulate the development of the thrombus simultaneously in time and space. Further development of computational approaches can provide quantitative insights leading to predictions that are not obvious from qualitative biological models.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Blood Coagulation*
  • Computational Biology*
  • Computer Simulation*
  • Fibrin / chemistry
  • Fibrin / metabolism
  • Fibrinogen / chemistry
  • Fibrinogen / metabolism
  • Humans
  • Kinetics
  • Models, Cardiovascular*
  • Platelet Activation
  • Protein Conformation
  • Structure-Activity Relationship
  • Thrombosis / blood*


  • Fibrin
  • Fibrinogen