Nanomechanical coupling enables detection and imaging of 5 nm superparamagnetic particles in liquid

Nanotechnology. 2011 Mar 25;22(12):125708. doi: 10.1088/0957-4484/22/12/125708. Epub 2011 Feb 17.

Abstract

We demonstrate that a force microscope operated in a bimodal mode enables the imaging and detection of superparamagnetic particles down to 5 nm. The bimodal method exploits the nanomechanical coupling of the excited modes to enhance the sensitivity of the higher mode to detect changes in material properties. The coupling requires the presence of nonlinear forces. Remarkably, bimodal operation enables us to identify changes of slowly varying forces (quasi-linear) in the presence of a stronger nonlinear force. Thus, unambiguous identification of single apoferritin (non-magnetic) and ferritin (magnetic) molecules in air and liquid is accomplished.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoferritins / ultrastructure
  • Ferritins / ultrastructure
  • Gold / chemistry
  • Horses
  • Magnetics
  • Metal Nanoparticles / chemistry
  • Metal Nanoparticles / ultrastructure
  • Microscopy, Atomic Force / methods*
  • Nanotechnology / methods*
  • Particle Size
  • Sensitivity and Specificity

Substances

  • Gold
  • Ferritins
  • Apoferritins