Acupressure has been found to be effective in a number of conditions. This study aims at determining the effectiveness of acupressure on physical stress among high school students. A quasi-experimental pretest/posttest control group design was used. Statistical analysis of data revealed that acupressure was effective in reducing physical stress among students within the study group (Z = -5.803, P < .001) and among students between the 2 study groups (Z = -7.409, P < .001).