New angucycline C-glycosides from Streptomyces sp. RI33

Jun-ya Ueda; Miho Izumikawa; Akira Mukai; Aya Nagai; Ji-Hwan Hwang; Motoki Takagi; Kazuo Shin-ya

doi:10.1038/ja.2011.8

New angucycline C-glycosides from Streptomyces sp. RI33

J Antibiot (Tokyo). 2011 May;64(5):367-72. doi: 10.1038/ja.2011.8. Epub 2011 Feb 16.

Authors

Jun-ya Ueda¹, Miho Izumikawa, Akira Mukai, Aya Nagai, Ji-Hwan Hwang, Motoki Takagi, Kazuo Shin-ya

Affiliation

¹ Biomedicinal Information Research Center (BIRC), Japan Biological Informatics Consortium (JBIC), Tokyo, Japan.

PMID: 21326253
DOI: 10.1038/ja.2011.8

Abstract

In the course of our screening program for anticancer agents from natural sources, five new angucyclines, JBIR-90 (1), -116 (2), -91 (3), -92 (4) and -93 (5), were isolated from the fermentation broth of Streptomyces sp. RI33. The structures of 1-5 were elucidated on the basis of 1D and 2D NMR spectroscopy and MS analyses. Compounds 2-4 showed cytotoxic activities against malignant pleural mesothelioma cells at IC(50) values of 20-50 μM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Fermentation
Glycosides / chemistry
Glycosides / isolation & purification
Glycosides / pharmacology*
Humans
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Mass Spectrometry
Mesothelioma / drug therapy*
Mesothelioma / pathology
Pleural Neoplasms / drug therapy*
Pleural Neoplasms / pathology
Streptomyces / metabolism*

Substances

Antineoplastic Agents
Glycosides