Ethical issues in developing pharmacogenetic research partnerships with American Indigenous communities

Clin Pharmacol Ther. 2011 Mar;89(3):343-5. doi: 10.1038/clpt.2010.303.


Pharmacogenetic research offers the potential to improve the safety and efficacy of drug prescribing. Assuring that the benefits of this research reach indigenous and other medically underserved people is an important justice concern. First, however, a legacy of mistrust, derived from traditional research practices that disempower communities, must be overcome. Linking pharmacogenetic research to collaborative, power-sharing research partnerships provides a valuable opportunity to develop new and positive precedents for genetic research in indigenous communities.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Community-Based Participatory Research / organization & administration
  • Cooperative Behavior
  • Drug-Related Side Effects and Adverse Reactions
  • Genetic Research / ethics*
  • Health Services Accessibility
  • Humans
  • Indians, North American*
  • Medically Underserved Area
  • Pharmaceutical Preparations / administration & dosage*
  • Pharmacogenetics / ethics*
  • Pharmacogenetics / organization & administration
  • Practice Patterns, Physicians'
  • Trust
  • United States


  • Pharmaceutical Preparations