Changes in calcium status in aged rats fed Lactobacillus GG and Bifidobacterium lactis and oligofructose-enriched inulin

Appl Physiol Nutr Metab. 2011 Feb;36(1):161-5. doi: 10.1139/H10-088.


In this study we hypothesized that an increase in numbers of beneficial bacteria in the large intestine can affect calcium (Ca) status in the elderly. Adult and aged rats were fed a diet with or without synbiotics for 21 days. Synbiotics increased the numbers of lactobacilli and bifidobacteria in large intestine in both adult and aged rats. The plasma Ca concentration was significantly increased while osteocalcin concentration was significantly decreased only in aged rats fed synbiotics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging
  • Animals
  • Bifidobacterium*
  • Calcium / blood*
  • Diet
  • Intestine, Large / microbiology
  • Inulin / pharmacology*
  • Lactobacillus*
  • Oligosaccharides / pharmacology*
  • Osteocalcin / blood
  • Pilot Projects
  • Rats
  • Rats, Sprague-Dawley
  • Synbiotics*


  • Oligosaccharides
  • oligofructose
  • Osteocalcin
  • Inulin
  • Calcium