New insights into the role of TFIIB in transcription initiation

Transcription. 2010 Nov;1(3):126-129. doi: 10.4161/trns.1.3.12900. Epub 2010 Jul 6.


The general transcription factor TFIIB plays essential, but as yet unclear, roles in transcription initiation by RNA polymerase II. We recently found that phosphorylation of TFIIB is required for productive transcription. We discuss the implications of this work for the functions of TFIIB in promoter escape and gene loop formation.