Mediator and post-recruitment regulation of RNA polymerase II

Transcription. Jan-Feb 2011;2(1):28-31. doi: 10.4161/trns.2.1.13950.

Abstract

The human Mediator complex interacts extensively with the RNA polymerase II (Pol II) enzyme and recent data from our lab suggest activator-induced structural shifts within Mediator trigger activation of stalled Pol II. These results are discussed together with other recent findings regarding post-recruitment regulation of Pol II.

Keywords: CDK8; DSIF; Myc; NELF; P-TEFb; p53; review.

MeSH terms

  • Humans
  • Mediator Complex / chemistry
  • Mediator Complex / metabolism*
  • Mediator Complex Subunit 1 / chemistry
  • Mediator Complex Subunit 1 / metabolism*
  • Models, Genetic
  • Mutation
  • Promoter Regions, Genetic / genetics
  • Protein Binding
  • Protein Conformation
  • Protein Subunits / chemistry
  • Protein Subunits / metabolism
  • RNA Polymerase II / metabolism*
  • Trans-Activators
  • Transcription, Genetic
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • MED1 protein, human
  • Med17 protein, human
  • Mediator Complex
  • Mediator Complex Subunit 1
  • Protein Subunits
  • Trans-Activators
  • Tumor Suppressor Protein p53
  • RNA Polymerase II