Transcriptional regulation underlying recovery from a DNA damage-induced arrest

Transcription. Jul-Aug 2010;1(1):32-5. doi: 10.4161/trns.1.1.12063.

Abstract

When the DNA of a cell is damaged, cell cycle progression is arrested and cell cycle-specific transcription is inhibited. However, cell cycle-specific transcription is required for eventual recovery from the DNA damage-induced arrest. Here we discuss recent findings that demonstrate how transcription is fine-tuned during the DNA damage response and how this controls the capacity to recover from a DNA damage arrest in G(2) phase.

Keywords: DNA damage; FoxM1; G2/M; Wip1; checkpoint recovery; mitotic entry; recovery competence.

MeSH terms

  • Animals
  • Cell Cycle
  • DNA Damage*
  • G2 Phase Cell Cycle Checkpoints*
  • Gene Expression Regulation*
  • Humans
  • Transcription, Genetic*