Antithrombotic therapies in patients with prosthetic heart valves: guidelines translated for the clinician

J Thromb Thrombolysis. 2011 May;31(4):514-22. doi: 10.1007/s11239-011-0574-9.


Patients with prosthetic heart valves require chronic oral anticoagulation. In this clinical scenario, physicians must be mindful of the thromboembolic and bleeding risks related to chronic anticoagulant therapy. Currently, only vitamin K antagonists are approved for this indication. This paper reviews the main heart valve guidelines focusing on the use of oral anticoagulation in these patients.

Publication types

  • Review

MeSH terms

  • Administration, Oral
  • Anticoagulants / administration & dosage*
  • Anticoagulants / adverse effects
  • Fibrinolytic Agents / administration & dosage*
  • Fibrinolytic Agents / adverse effects
  • Heart Valve Prosthesis*
  • Humans
  • Practice Guidelines as Topic
  • Thromboembolism / prevention & control*
  • Vitamin K / antagonists & inhibitors*


  • Anticoagulants
  • Fibrinolytic Agents
  • Vitamin K