Ceftriaxone treatment failure of pharyngeal gonorrhoea verified by international recommendations, Sweden, July 2010

Euro Surveill. 2011 Feb 10;16(6):19792.


This report describes one case of verified treatment failure of pharyngeal gonorrhoea using ceftriaxone in Sweden. Previous reports described verified treatment failure of urogenital gonorrhoea using the internationally recommended first-line drug cefixime, but not with ceftriaxone, the last remaining option for empirical treatment of gonorrhoea. Enhanced awareness of clinical failures, pharmacodynamic considerations, follow-up and test of cure, adherence to appropriate case management and treatment guidelines as well as verification/falsification of presumed clinical treatment failures should be emphasised worldwide.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Ceftriaxone / therapeutic use*
  • Dose-Response Relationship, Drug
  • Drug Resistance, Bacterial
  • Gonorrhea / diagnosis
  • Gonorrhea / drug therapy*
  • Gonorrhea / microbiology
  • Heterosexuality
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Neisseria gonorrhoeae / drug effects*
  • Neisseria gonorrhoeae / genetics
  • Neisseria gonorrhoeae / isolation & purification*
  • Pharyngeal Diseases / diagnosis
  • Pharyngeal Diseases / drug therapy*
  • Pharyngeal Diseases / microbiology
  • Polymerase Chain Reaction
  • Practice Guidelines as Topic
  • Sequence Analysis, DNA
  • Sweden
  • Treatment Failure
  • Young Adult


  • Anti-Bacterial Agents
  • Ceftriaxone