Review
doi: 10.1016/j.ejps.2011.02.004.
Epub 2011 Feb 15.
Cimetidine: an anticancer drug?
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- PMID: 21329756
- DOI: 10.1016/j.ejps.2011.02.004
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Review
Cimetidine: an anticancer drug?
Eur J Pharm Sci.
.
Abstract
Cimetidine, H(2) receptor antagonists, is commonly prescribed for gastric and duodenal ulcer disease. Additionally, cimetidine has been shown to have anticancer effects. This review describes the mechanism of antitumor action of cimetidine including its ability to interfere with tumor cell adhesion, angiogenesis and proliferation; its effect on the immune system; as well as inhibition of postoperative immunosuppression. Its anticancer effect is also compared to that of the other H(2) receptor antagonists as well as outcomes of cimetidine in clinical studies in cancer patients.
Copyright © 2011 Elsevier B.V. All rights reserved.
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